Aging-dependent demethylation of regulatory elements correlates with chromatin state and improved β-cell function

Aging is driven by changes of the epigenetic state that are only partially understood. We performed a comprehensive epigenomic analysis of the pancreatic β cell, key player in glucose homeostasis, in adolescent and very old mice. We observe a global methylation drift resulting in an overall more lev...

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Bibliografiske detaljer
Udgivet i:Cell Metab
Main Authors: Avrahami, Dana, Li, Changhong, Zhang, Jia, Schug, Jonathan, Avrahami, Ran, Rao, Shilpa, Stadler, Michael B., Burger, Lukas, Schübeler, Dirk, Glaser, Benjamin, Kaestner, Klaus H.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4598285/
https://ncbi.nlm.nih.gov/pubmed/26321660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2015.07.025
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