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Cell cycle-resolved chromatin proteomics reveals the extent of mitotic preservation of the genomic regulatory landscape

Regulation of transcription, replication, and cell division relies on differential protein binding to DNA and chromatin, yet it is unclear which regulatory components remain bound to compacted mitotic chromosomes. By utilizing the buoyant density of DNA–protein complexes after cross-linking, we here...

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Bibliographische Detailangaben
Veröffentlicht in:Nat Commun
Hauptverfasser: Ginno, Paul Adrian, Burger, Lukas, Seebacher, Jan, Iesmantavicius, Vytautas, Schübeler, Dirk
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6168604/
https://ncbi.nlm.nih.gov/pubmed/30279501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06007-5
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