Targeting the cell cycle inhibitor p57(Kip2) promotes adult human β cell replication

Children with focal hyperinsulinism of infancy display a dramatic, non-neoplastic clonal expansion of β cells that have undergone mitotic recombination, resulting in paternal disomy of part of chromosome 11. This disomic region contains imprinted genes, including the gene encoding the cell cycle inh...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Avrahami, Dana, Li, Changhong, Yu, Ming, Jiao, Yang, Zhang, Jia, Naji, Ali, Ziaie, Seyed, Glaser, Benjamin, Kaestner, Klaus H.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Clinical Investigation 2014
Pynciau:
Brief Report
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3904605/
https://ncbi.nlm.nih.gov/pubmed/24430183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI69519
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