Targeted demethylation at the CDKN1C/p57 locus induces human β cell replication

The loss of insulin-secreting β cells is characteristic among type I and type II diabetes. Stimulating proliferation to expand sources of β cells for transplantation remains a challenge because adult β cells do not proliferate readily. The cell cycle inhibitor p57 has been shown to control cell divi...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:J Clin Invest
Hlavní autoři: Ou, Kristy, Yu, Ming, Moss, Nicholas G., Wang, Yue J., Wang, Amber W., Nguyen, Son C., Jiang, Connie, Feleke, Eseye, Kameswaran, Vasumathi, Joyce, Eric F., Naji, Ali, Glaser, Benjamin, Avrahami, Dana, Kaestner, Klaus H.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2018
Témata:
Concise Communication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6307972/
https://ncbi.nlm.nih.gov/pubmed/30352048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI99170
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky