Single-cell transcriptomics of human islet ontogeny defines the molecular basis of β-cell dedifferentiation in T2D

OBJECTIVE: Dedifferentiation of pancreatic β-cells may reduce islet function in type 2 diabetes (T2D). However, the prevalence, plasticity and functional consequences of this cellular state remain unknown. METHODS: We employed single-cell RNAseq to detail the maturation program of α- and β-cells dur...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Mol Metab
Main Authors: Avrahami, Dana, Wang, Yue J., Schug, Jonathan, Feleke, Eseye, Gao, Long, Liu, Chengyang, Naji, Ali, Glaser, Benjamin, Kaestner, Klaus H.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7471622/
https://ncbi.nlm.nih.gov/pubmed/32739450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2020.101057
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados