Single-cell transcriptomics of human islet ontogeny defines the molecular basis of β-cell dedifferentiation in T2D

OBJECTIVE: Dedifferentiation of pancreatic β-cells may reduce islet function in type 2 diabetes (T2D). However, the prevalence, plasticity and functional consequences of this cellular state remain unknown. METHODS: We employed single-cell RNAseq to detail the maturation program of α- and β-cells dur...

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Vydáno v:Mol Metab
Hlavní autoři: Avrahami, Dana, Wang, Yue J., Schug, Jonathan, Feleke, Eseye, Gao, Long, Liu, Chengyang, Naji, Ali, Glaser, Benjamin, Kaestner, Klaus H.
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2020
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7471622/
https://ncbi.nlm.nih.gov/pubmed/32739450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2020.101057
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