PAX6 maintains β cell identity by repressing genes of alternative islet cell types

Type 2 diabetes is thought to involve a compromised β cell differentiation state, but the mechanisms underlying this dysfunction remain unclear. Here, we report a key role for the TF PAX6 in the maintenance of adult β cell identity and function. PAX6 was downregulated in β cells of diabetic db/db mi...

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Bibliografiske detaljer
Udgivet i:J Clin Invest
Main Authors: Swisa, Avital, Avrahami, Dana, Eden, Noa, Zhang, Jia, Feleke, Eseye, Dahan, Tehila, Cohen-Tayar, Yamit, Stolovich-Rain, Miri, Kaestner, Klaus H., Glaser, Benjamin, Ashery-Padan, Ruth, Dor, Yuval
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5199694/
https://ncbi.nlm.nih.gov/pubmed/27941241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI88015
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