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PAX6 maintains β cell identity by repressing genes of alternative islet cell types
Type 2 diabetes is thought to involve a compromised β cell differentiation state, but the mechanisms underlying this dysfunction remain unclear. Here, we report a key role for the TF PAX6 in the maintenance of adult β cell identity and function. PAX6 was downregulated in β cells of diabetic db/db mi...
Gardado en:
| Publicado en: | J Clin Invest |
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| Main Authors: | , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society for Clinical Investigation
2016
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5199694/ https://ncbi.nlm.nih.gov/pubmed/27941241 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI88015 |
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