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β-Cell DNA Damage Response Promotes Islet Inflammation in Type 1 Diabetes
Type 1 diabetes (T1D) is an autoimmune disease where pancreatic β-cells are destroyed by islet-infiltrating T cells. Although a role for β-cell defects has been suspected, β-cell abnormalities are difficult to demonstrate. We show a β-cell DNA damage response (DDR), presented by activation of the 53...
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| Publicat a: | Diabetes |
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| Autors principals: | , , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Diabetes Association
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6198335/ https://ncbi.nlm.nih.gov/pubmed/30150306 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db17-1006 |
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