β-Cell DNA Damage Response Promotes Islet Inflammation in Type 1 Diabetes

Type 1 diabetes (T1D) is an autoimmune disease where pancreatic β-cells are destroyed by islet-infiltrating T cells. Although a role for β-cell defects has been suspected, β-cell abnormalities are difficult to demonstrate. We show a β-cell DNA damage response (DDR), presented by activation of the 53...

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Detalhes bibliográficos
Publicado no:Diabetes
Main Authors: Horwitz, Elad, Krogvold, Lars, Zhitomirsky, Sophia, Swisa, Avital, Fischman, Maya, Lax, Tsuria, Dahan, Tehila, Hurvitz, Noa, Weinberg-Corem, Noa, Klochendler, Agnes, Powers, Alvin C., Brissova, Marcela, Jörns, Anne, Lenzen, Sigurd, Glaser, Benjamin, Dahl-Jørgensen, Knut, Dor, Yuval
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2018
Assuntos:
Islet Studies
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6198335/
https://ncbi.nlm.nih.gov/pubmed/30150306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db17-1006
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