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The Role of Collagen Charge Clusters in the Modulation of Matrix Metalloproteinase Activity

Members of the matrix metalloproteinase (MMP) family selectively cleave collagens in vivo. Several substrate structural features that direct MMP collagenolysis have been identified. The present study evaluated the role of charged residue clusters in the regulation of MMP collagenolysis. A series of...

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Autori principali: Lauer, Janelle L., Bhowmick, Manishabrata, Tokmina-Roszyk, Dorota, Lin, Yan, Van Doren, Steven R., Fields, Gregg B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3900948/
https://ncbi.nlm.nih.gov/pubmed/24297171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.513408
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