Path to Collagenolysis: COLLAGEN V TRIPLE-HELIX MODEL BOUND PRODUCTIVELY AND IN ENCOUNTERS BY MATRIX METALLOPROTEINASE-12

Collagenolysis is essential in extracellular matrix homeostasis, but its structural basis has long been shrouded in mystery. We have developed a novel docking strategy guided by paramagnetic NMR that positions a triple-helical collagen V mimic (synthesized with nitroxide spin labels) in the active s...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Prior, Stephen H., Byrne, Todd S., Tokmina-Roszyk, Dorota, Fields, Gregg B., Van Doren, Steven R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Molecular Biophysics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4824997/
https://ncbi.nlm.nih.gov/pubmed/26887942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.703124
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