Alteration and activation of sequence-specific cleavage of DNA by bleomycin in the presence of the antitumor drug cis-diamminedichloroplatinum(II).

The antitumor drug cis-diamminedichloroplatinum(II) dramatically alters the sequence-specific cleavage of the bleomycin A2-iron(II)-O2 system. Preferred bleomycin cleavage sites adjacent to oligo(dG) regions on two restriction fragments of plasmid pBR322 DNA were masked by pretreatment with cis-diam...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Mascharak, P K, Sugiura, Y, Kuwahara, J, Suzuki, T, Lippard, S J
Materialtyp: Artigo
Språk:Inglês
Publicerad: 1983
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC390072/
https://ncbi.nlm.nih.gov/pubmed/6196777
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk