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Ethidium bromide changes the nuclease-sensitive DNA binding sites of the antitumor drug cis-diamminedichloroplatinum(II).

Exonuclease III has been shown previously to reveal the binding sites of the antitumor drug cis-diamminedichloroplatinum(II) on DNA. Pretreatment of the same DNA with the intercalator ethidium bromide causes new platinum binding sites to be detected by the exonuclease III method. In particular, a 5&...

詳細記述

保存先:
書誌詳細
出版年:Proc Natl Acad Sci U S A
主要な著者: Tullius, T D, Lippard, S J
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 1982
主題:
オンライン・アクセス:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC346446/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6954494/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.79.11.3489
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