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Ethidium bromide changes the nuclease-sensitive DNA binding sites of the antitumor drug cis-diamminedichloroplatinum(II).

Exonuclease III has been shown previously to reveal the binding sites of the antitumor drug cis-diamminedichloroplatinum(II) on DNA. Pretreatment of the same DNA with the intercalator ethidium bromide causes new platinum binding sites to be detected by the exonuclease III method. In particular, a 5&...

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Bibliografski detalji
Glavni autori: Tullius, T D, Lippard, S J
Format: Artigo
Jezik:Inglês
Izdano: 1982
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC346446/
https://ncbi.nlm.nih.gov/pubmed/6954494
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