Ethidium bromide changes the nuclease-sensitive DNA binding sites of the antitumor drug cis-diamminedichloroplatinum(II).

Exonuclease III has been shown previously to reveal the binding sites of the antitumor drug cis-diamminedichloroplatinum(II) on DNA. Pretreatment of the same DNA with the intercalator ethidium bromide causes new platinum binding sites to be detected by the exonuclease III method. In particular, a 5'...

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Bibliografische gegevens

Gepubliceerd in:	Proc Natl Acad Sci U S A
Hoofdauteurs:	Tullius, T D, Lippard, S J
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	National Academy of Sciences 1982
Onderwerpen:	Research Article
Online toegang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC346446/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6954494/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.79.11.3489
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