Alteration and activation of sequence-specific cleavage of DNA by bleomycin in the presence of the antitumor drug cis-diamminedichloroplatinum(II).

The antitumor drug cis-diamminedichloroplatinum(II) dramatically alters the sequence-specific cleavage of the bleomycin A2-iron(II)-O2 system. Preferred bleomycin cleavage sites adjacent to oligo(dG) regions on two restriction fragments of plasmid pBR322 DNA were masked by pretreatment with cis-diam...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Mascharak, P K, Sugiura, Y, Kuwahara, J, Suzuki, T, Lippard, S J
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1983
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC390072/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6196777/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.80.22.6795
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