Divergent Phenotypes in Mutant TDP-43 Transgenic Mice Highlight Potential Confounds in TDP-43 Transgenic Modeling

The majority of cases of frontotemporal lobar degeneration and amyotrophic lateral sclerosis are pathologically defined by the cleavage, cytoplasmic redistribution and aggregation of TAR DNA binding protein of 43 kDa (TDP-43). To examine the contribution of these potentially toxic mechanisms in vivo...

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Détails bibliographiques
Auteurs principaux: D’Alton, Simon, Altshuler, Marcelle, Cannon, Ashley, Dickson, Dennis W., Petrucelli, Leonard, Lewis, Jada
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2014
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3899264/
https://ncbi.nlm.nih.gov/pubmed/24466128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0086513
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