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Studies of alternative isoforms provide insight into TDP-43 autoregulation and pathogenesis
TDP-43 is a soluble, nuclear protein that undergoes cytoplasmic redistribution and aggregation in the majority of cases of amyotrophic lateral sclerosis and frontotemporal lobar degeneration. TDP-43 autoregulates the abundance of its own transcript TARDBP by binding to an intron in the 3′ untranslat...
Gorde:
| Argitaratua izan da: | RNA |
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| Egile Nagusiak: | , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
Cold Spring Harbor Laboratory Press
2015
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4509932/ https://ncbi.nlm.nih.gov/pubmed/26089325 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.047647.114 |
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