Molecularly Self-Assembled Nucleic Acid Nanoparticles for Targeted In Vivo siRNA Delivery

Nanoparticles are employed for delivering therapeutics into cells(1,2). However, size, shape, surface chemistry and the presentation of targeting ligands on the surface of nanoparticles can affect circulation half-life and biodistribution, cell specific internalization, excretion, toxicity, and effi...

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Hlavní autoři: Lee, Hyukjin, Lytton-Jean, Abigail K. R., Chen, Yi, Love, Kevin T., Park, Angela I., Karagiannis, Emmanouil D., Sehgal, Alfica, Querbes, William, Zurenko, Christopher S., Jayaraman, Muthusamy, Peng, Chang G., Charisse, Klaus, Borodovsky, Anna, Manoharan, Muthiah, Donahoe, Jessica S., Truelove, Jessica, Nahrendorf, Matthias, Langer, Robert, Anderson, Daniel G.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3898745/
https://ncbi.nlm.nih.gov/pubmed/22659608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nnano.2012.73
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