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Visualizing lipid-formulated siRNA release from endosomes and target gene knockdown
A central hurdle in developing small interfering RNAs (siRNAs) as therapeutics is the inefficiency of their delivery across the plasma and endosomal membranes to the cytosol, where they interact with the RNA interference machinery. With the aim of improving endosomal release, a poorly understood and...
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| Gepubliceerd in: | Nat Biotechnol |
|---|---|
| Hoofdauteurs: | , , , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2015
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4663660/ https://ncbi.nlm.nih.gov/pubmed/26192320 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.3298 |
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