Visualizing lipid-formulated siRNA release from endosomes and target gene knockdown

A central hurdle in developing small interfering RNAs (siRNAs) as therapeutics is the inefficiency of their delivery across the plasma and endosomal membranes to the cytosol, where they interact with the RNA interference machinery. With the aim of improving endosomal release, a poorly understood and...

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Detaylı Bibliyografya
Yayımlandı:Nat Biotechnol
Asıl Yazarlar: Wittrup, Anders, Ai, Angela, Liu, Xing, Hamar, Peter, Trifonova, Radiana, Charisse, Klaus, Manoharan, Muthiah, Kirchhausen, Tomas, Lieberman, Judy
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2015
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4663660/
https://ncbi.nlm.nih.gov/pubmed/26192320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.3298
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