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Novel siRNA formulation to effectively knockdown mutant p53 in osteosarcoma
OBJECTIVES: The tumor suppressor p53 plays a crucial role in the development of osteosarcoma. The primary objective of this study is to develop and optimize lipid based nanoparticle formulations that can carry siRNA and effectively silence mutant p53 in 318–1, a murine osteosarcoma cell line. METHOD...
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| Publicado no: | PLoS One |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5479560/ https://ncbi.nlm.nih.gov/pubmed/28636657 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0179168 |
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