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Imaging small molecule-induced endosomal escape of siRNA
Small interfering RNAs (siRNAs) are a new class of promising therapeutic molecules that can be used for sequence-specific downregulation of disease-causing genes. However, endosomal entrapment of siRNA is a key hurdle for most delivery strategies, limiting the therapeutic effect. Here, we use live-c...
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| Izdano u: | Nat Commun |
|---|---|
| Glavni autori: | , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Publishing Group UK
2020
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7156650/ https://ncbi.nlm.nih.gov/pubmed/32286269 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15300-1 |
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