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Imaging small molecule-induced endosomal escape of siRNA

Small interfering RNAs (siRNAs) are a new class of promising therapeutic molecules that can be used for sequence-specific downregulation of disease-causing genes. However, endosomal entrapment of siRNA is a key hurdle for most delivery strategies, limiting the therapeutic effect. Here, we use live-c...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Du Rietz, Hampus, Hedlund, Hampus, Wilhelmson, Sten, Nordenfelt, Pontus, Wittrup, Anders
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7156650/
https://ncbi.nlm.nih.gov/pubmed/32286269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15300-1
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