Intracellular processing of immunostimulatory CpG-siRNA: Toll-like receptor 9 facilitates siRNA dicing and endosomal escape

Dicer-substrate siRNAs equipped with CpG oligodeoxyribonucleotides overcome the major hurdle in cell-specific siRNA delivery. The CpG-siRNA molecules are actively internalized by TLR9(+) cells, without the need for transfection reagents, leading to RNA interference both in vitro and in vivo. Here, w...

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Hauptverfasser: Nechaev, Sergey, Gao, Chan, Moreira, Dayson, Swiderski, Piotr, Jozwiak, Agnieszka, Kowolik, Claudia M., Zhou, Jiehua, Armstrong, Brian, Raubitschek, Andrew, Rossi, John J., Kortylewski, Marcin
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3742675/
https://ncbi.nlm.nih.gov/pubmed/23777886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2013.06.007
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