Rational Design of Immunostimulatory siRNAs

Short-interfering RNAs (siRNAs) have engendered much enthusiasm for their ability to silence the expression of specific genes. However, it is now well established that siRNAs, depending on their sequence, can be variably sensed by the innate immune system through recruitment of toll-like receptors 7...

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Autores principales: Gantier, Michael P, Tong, Stephen, Behlke, Mark A, Irving, Aaron T, Lappas, Martha, Nilsson, Ulrika W, Latz, Eicke, McMillan, Nigel AJ, Williams, Bryan RG
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2010
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Original Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2862527/
https://ncbi.nlm.nih.gov/pubmed/20125126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2010.4
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