Rational Design of Immunostimulatory siRNAs

Short-interfering RNAs (siRNAs) have engendered much enthusiasm for their ability to silence the expression of specific genes. However, it is now well established that siRNAs, depending on their sequence, can be variably sensed by the innate immune system through recruitment of toll-like receptors 7...

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Detalhes bibliográficos
Main Authors: Gantier, Michael P, Tong, Stephen, Behlke, Mark A, Irving, Aaron T, Lappas, Martha, Nilsson, Ulrika W, Latz, Eicke, McMillan, Nigel AJ, Williams, Bryan RG
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2010
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2862527/
https://ncbi.nlm.nih.gov/pubmed/20125126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2010.4
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