Modulation of Ras signaling alters the toxicity of hydroquinone, a benzene metabolite and component of cigarette smoke

BACKGROUND: Benzene is an established human leukemogen, with a ubiquitous environmental presence leading to significant population exposure. In a genome-wide functional screen in the yeast Saccharomyces cerevisiae, inactivation of IRA2, a yeast ortholog of the human tumor suppressor gene NF1 (Neurof...

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Detalhes bibliográficos
Main Authors: North, Matthew, Shuga, Joe, Fromowitz, Michele, Loguinov, Alexandre, Shannon, Kevin, Zhang, Luoping, Smith, Martyn T, Vulpe, Chris D
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3898384/
https://ncbi.nlm.nih.gov/pubmed/24386979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-14-6
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