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Modulation of Ras signaling alters the toxicity of hydroquinone, a benzene metabolite and component of cigarette smoke
BACKGROUND: Benzene is an established human leukemogen, with a ubiquitous environmental presence leading to significant population exposure. In a genome-wide functional screen in the yeast Saccharomyces cerevisiae, inactivation of IRA2, a yeast ortholog of the human tumor suppressor gene NF1 (Neurof...
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主要な著者: | , , , , , , , |
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フォーマット: | Artigo |
言語: | Inglês |
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BioMed Central
2014
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オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3898384/ https://ncbi.nlm.nih.gov/pubmed/24386979 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-14-6 |
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