The benzene metabolite, hydroquinone and etoposide both induce endoreduplication in human lymphoblastoid TK6 cells

Both occupational exposure to the leukemogen benzene and in vitro exposure to its metabolite hydroquinone (HQ) lead to the induction of numerical and structural chromosome changes. Several studies have shown that HQ can form DNA adducts, disrupt microtubule assembly and inhibit DNA topoisomerase II...

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Autors principals: Ji, Zhiying, Zhang, Luoping, Guo, Weihong, McHale, Cliona M., Smith, Martyn T.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2009
Matèries:
Original Papers
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2701990/
https://ncbi.nlm.nih.gov/pubmed/19491217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/mutage/gep018
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