Suppression of Aβ toxicity by puromycin-sensitive aminopeptidase is independent of its proteolytic activity()

The accumulation of β-amyloid (Aβ) peptide in the brain is one of the pathological hallmarks of Alzheimer's disease and is thought to be of primary aetiological significance. In an unbiased genetic screen, we identified puromycin-sensitive aminopeptidase (PSA) as a potent suppressor of Aβ toxic...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Kruppa, Antonina J., Ott, Stanislav, Chandraratna, Dhia S., Irving, James A., Page, Richard M., Speretta, Elena, Seto, Tiffany, Camargo, Luiz Miguel, Marciniak, Stefan J., Lomas, David A., Crowther, Damian C.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Elsevier Pub. Co 2013
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3898073/
https://ncbi.nlm.nih.gov/pubmed/23911349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2013.07.019
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