Suppression of Aβ toxicity by puromycin-sensitive aminopeptidase is independent of its proteolytic activity()

The accumulation of β-amyloid (Aβ) peptide in the brain is one of the pathological hallmarks of Alzheimer's disease and is thought to be of primary aetiological significance. In an unbiased genetic screen, we identified puromycin-sensitive aminopeptidase (PSA) as a potent suppressor of Aβ toxic...

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Main Authors: Kruppa, Antonina J., Ott, Stanislav, Chandraratna, Dhia S., Irving, James A., Page, Richard M., Speretta, Elena, Seto, Tiffany, Camargo, Luiz Miguel, Marciniak, Stefan J., Lomas, David A., Crowther, Damian C.
Format: Artigo
Jezik:Inglês
Izdano: Elsevier Pub. Co 2013
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3898073/
https://ncbi.nlm.nih.gov/pubmed/23911349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2013.07.019
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