Suppression of Aβ toxicity by puromycin-sensitive aminopeptidase is independent of its proteolytic activity()

The accumulation of β-amyloid (Aβ) peptide in the brain is one of the pathological hallmarks of Alzheimer's disease and is thought to be of primary aetiological significance. In an unbiased genetic screen, we identified puromycin-sensitive aminopeptidase (PSA) as a potent suppressor of Aβ toxic...

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Detalhes bibliográficos
Main Authors: Kruppa, Antonina J., Ott, Stanislav, Chandraratna, Dhia S., Irving, James A., Page, Richard M., Speretta, Elena, Seto, Tiffany, Camargo, Luiz Miguel, Marciniak, Stefan J., Lomas, David A., Crowther, Damian C.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Pub. Co 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3898073/
https://ncbi.nlm.nih.gov/pubmed/23911349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2013.07.019
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