Puromycin-Sensitive Aminopeptidase: An Antiviral Prodrug Activating Enzyme

Cidofovir (HPMPC) is a broad-spectrum antiviral agent, currently used to treat AIDS-related human cytomegalovirus retinitis. Cidofovir has recognized therapeutic potential for orthopox virus infections, although its use is hampered by its inherent low oral bioavailability. Val-Ser-cyclic HPMPC (Val-...

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Bibliographische Detailangaben
Hauptverfasser: Tehler, Ulrika, Nelson, Cara H., Peterson, Larryn W., Provoda, Chester J., Hilfinger, John M., Lee, Kyung-Dall, McKenna, Charles E., Amidon, Gordon L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2830364/
https://ncbi.nlm.nih.gov/pubmed/19969024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.antiviral.2009.12.003
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