Synthesis, transport and antiviral activity of Ala-Ser and Val-Ser prodrugs of cidofovir

We report the synthesis and biological evaluation of Ala-(Val-)L-Ser-CO(2)R prodrugs of 1, where a dipeptide promoiety is conjugated to the P(OH)(2) group of cidofovir (1) via esterification by the Ser side chain hydroxyl group and an ethyl group (4 and 5) or alone (6 and 7). In a murine model, oral...

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Bibliografiset tiedot
Päätekijät: Peterson, Larryn W., Kim, Jae-Seung, Kijek, Paul, Mitchell, Stefanie, Hilfinger, John, Breitenbach, Julie, Borysko, Kathy, Drach, John C., Kashemirov, Boris A., McKenna, Charles E.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2011
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3115518/
https://ncbi.nlm.nih.gov/pubmed/21641218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2011.04.126
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