Synthesis and biological activation of an ethylene glycol-linked amino acid conjugate of cyclic cidofovir

Cidofovir (HPMPC) is a broad-spectrum anti-viral agent whose potential, particularly in biodefense scenarios, is limited by its low oral bioavailability. Two prodrugs (3, 4) created by conjugating ethylene glycol-linked amino acids (L-Val, L-Phe) with the cyclic form of cidofovir (cHPMPC) via a P-O...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Eriksson, Ulrika, Hilfinger, John M., Kim, Jae-Seung, Mitchell, Stefanie, Kijek, Paul, Borysko, Katherine Z., Breitenbach, Julie M., Drach, John C., Kashemirov, Boris A., McKenna, Charles E.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2006
Materias:
Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1899532/
https://ncbi.nlm.nih.gov/pubmed/17161946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2006.11.012
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares