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Synthesis and biological activation of an ethylene glycol-linked amino acid conjugate of cyclic cidofovir
Cidofovir (HPMPC) is a broad-spectrum anti-viral agent whose potential, particularly in biodefense scenarios, is limited by its low oral bioavailability. Two prodrugs (3, 4) created by conjugating ethylene glycol-linked amino acids (L-Val, L-Phe) with the cyclic form of cidofovir (cHPMPC) via a P-O...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1899532/ https://ncbi.nlm.nih.gov/pubmed/17161946 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2006.11.012 |
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