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Evolution of an Amino Acid-based Prodrug Approach: Stay Tuned
Certain acyclic nucleoside phosphonates (ANPs) such as (S)-HPMPC (cidofovir, Vistide(®)) and (S)-HPMPA have been shown to be active against a broad spectrum of DNA and retroviruses. However, their poor absorption as well as their toxicity limit the utilization of these therapeutics in the clinic. Nu...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3788118/ https://ncbi.nlm.nih.gov/pubmed/23339402 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp300663j |
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