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The structure of cyclic nucleoside phosphonate ester prodrugs: an inquiry
[Image: see text] The configuration at phosphorus in cyclic (S)-HPMPC (1, Cidofovir) and (S)-HPMPA (2) phenyl ester (5 and 6, respectively) diastereomers ((R(p))-5, (R(p))-6, (S(p))-6) were determined by X-ray crystallography and correlated to their (1)H and (31)P NMR spectra in solution. (R(p))-5 a...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2011
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3254244/ https://ncbi.nlm.nih.gov/pubmed/22126969 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo201735f |
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