Serine Peptide Phosphoester Prodrugs of Cyclic Cidofovir: Synthesis, Transport, and Antiviral Activity

Cidofovir (HPMPC, 1), a broad-spectrum antiviral agent, is currently used to treat AIDS-related human cytomegalovirus (HCMV) retinitis and has recognized therapeutic potential for orthopox virus infections, but is limited by its low oral bioavailability. Cyclic cidofovir (2) displays decreased nephr...

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Detalhes bibliográficos
Main Authors: Eriksson, Ulrika, Peterson, Larryn W., Kashemirov, Boris A., Hilfinger, John M., Drach, John C., Borysko, Katherine Z., Breitenbach, Julie M., Kim, Jae Seung, Mitchell, Stefanie, Kijek, Paul, McKenna, Charles E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2629803/
https://ncbi.nlm.nih.gov/pubmed/18481868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp8000099
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