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Design and synthesis of vidarabine prodrugs as antiviral agents
5′-O-D- and L-amino acid derivatives and 5′-O-(D- and L-amino acid methyl ester phosphoramidate) derivatives of vidarabine (ara-A) were synthesized as vidarabine prodrugs. Some compounds were equi- or more potent in vitro than vidarabine against two pox viruses and their uptake by cultured cells was...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2642980/ https://ncbi.nlm.nih.gov/pubmed/19097789 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2008.12.031 |
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