Design and synthesis of vidarabine prodrugs as antiviral agents

5′-O-D- and L-amino acid derivatives and 5′-O-(D- and L-amino acid methyl ester phosphoramidate) derivatives of vidarabine (ara-A) were synthesized as vidarabine prodrugs. Some compounds were equi- or more potent in vitro than vidarabine against two pox viruses and their uptake by cultured cells was...

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Detaylı Bibliyografya
Asıl Yazarlar: Shen, Wei, Kim, Jae-Seung, Kish, Phillip E., Zhang, Jie, Mitchell, Stefanie, Gentry, Brian G., Breitenbach, Julie M., Drach, John C., Hilfinger, John
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2008
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2642980/
https://ncbi.nlm.nih.gov/pubmed/19097789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2008.12.031
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