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Specificity of a Prodrug-Activating Enzyme hVACVase: the Leaving Group Effect
Human valacyclovirase (hVACVase) is a prodrug-activating enzyme for amino acid prodrugs including the antiviral drugs valacyclovir and valganciclovir. In hVACVase-catalyzed reactions, the leaving group of the substrate corresponds to the drug moiety of the prodrug, making the leaving group effect es...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2010
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2997884/ https://ncbi.nlm.nih.gov/pubmed/21028903 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp100300k |
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