Molecular Basis of Prodrug Activation by Human Valacyclovirase, an α-Amino Acid Ester Hydrolase

Chemical modification to improve biopharmaceutical properties, especially oral absorption and bioavailability, is a common strategy employed by pharmaceutical chemists. The approach often employs a simple structural modification and utilizes ubiquitous endogenous esterases as activation enzymes, alt...

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Detaylı Bibliyografya
Asıl Yazarlar: Lai, Longsheng, Xu, Zhaohui, Zhou, Jiahai, Lee, Kyung-Dall, Amidon, Gordon L.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2008
Konular:
Enzyme Catalysis and Regulation
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2431032/
https://ncbi.nlm.nih.gov/pubmed/18256025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M709530200
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