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Enhancing the Intestinal Membrane Permeability of Zanamivir: A Carrier Mediated Prodrug Approach
The purpose of this study was to improve the membrane permeability and oral absorption of the poorly permeable anti-influenza agent, zanamivir. The poor oral bioavailability is attributed to the high polarity (cLogP~-5) resulting from the polar and zwitterionic nature of zanamivir. In order to impro...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3304100/ https://ncbi.nlm.nih.gov/pubmed/21905667 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp200291x |
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