Serine Hydrolase Inhibitors Block Necrotic Cell Death by Preventing Calcium Overload of the Mitochondria and Permeability Transition Pore Formation

Perturbation of calcium signaling that occurs during cell injury and disease, promotes cell death. In mouse lung fibroblasts A23187 triggered mitochondrial permeability transition pore (MPTP) formation, lactate dehydrogenase (LDH) release, and necrotic cell death that were blocked by cyclosporin A (...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Yun, Bogeon, Lee, HeeJung, Ghosh, Moumita, Cravatt, Benjamin F., Hsu, Ku-Lung, Bonventre, Joseph V., Ewing, Heather, Gelb, Michael H., Leslie, Christina C.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2014
נושאים:
Cell Biology
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3894331/
https://ncbi.nlm.nih.gov/pubmed/24297180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.497651
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