Serine Hydrolase Inhibitors Block Necrotic Cell Death by Preventing Calcium Overload of the Mitochondria and Permeability Transition Pore Formation

Perturbation of calcium signaling that occurs during cell injury and disease, promotes cell death. In mouse lung fibroblasts A23187 triggered mitochondrial permeability transition pore (MPTP) formation, lactate dehydrogenase (LDH) release, and necrotic cell death that were blocked by cyclosporin A (...

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Detalhes bibliográficos
Main Authors: Yun, Bogeon, Lee, HeeJung, Ghosh, Moumita, Cravatt, Benjamin F., Hsu, Ku-Lung, Bonventre, Joseph V., Ewing, Heather, Gelb, Michael H., Leslie, Christina C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3894331/
https://ncbi.nlm.nih.gov/pubmed/24297180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.497651
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