Serine Hydrolase Inhibitors Block Necrotic Cell Death by Preventing Calcium Overload of the Mitochondria and Permeability Transition Pore Formation

Perturbation of calcium signaling that occurs during cell injury and disease, promotes cell death. In mouse lung fibroblasts A23187 triggered mitochondrial permeability transition pore (MPTP) formation, lactate dehydrogenase (LDH) release, and necrotic cell death that were blocked by cyclosporin A (...

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Hlavní autoři: Yun, Bogeon, Lee, HeeJung, Ghosh, Moumita, Cravatt, Benjamin F., Hsu, Ku-Lung, Bonventre, Joseph V., Ewing, Heather, Gelb, Michael H., Leslie, Christina C.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2014
Témata:
Cell Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3894331/
https://ncbi.nlm.nih.gov/pubmed/24297180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.497651
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