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Vitamin C induces Tet-dependent DNA demethylation in ESCs to promote a blastocyst-like state
DNA methylation is a heritable epigenetic modification involved in gene silencing, imprinting, and the suppression of retrotransposons(1). Global DNA demethylation occurs in the early embryo and the germline(2,3) and may be mediated by Tet (ten-eleven-translocation) enzymes(4–6), which convert 5-met...
में बचाया:
| मुख्य लेखकों: | , , , , , , , , , , , |
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| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
2013
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3893718/ https://ncbi.nlm.nih.gov/pubmed/23812591 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature12362 |
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