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Roles of TET and TDG in DNA demethylation in proliferating and non-proliferating immune cells
BACKGROUND: TET enzymes mediate DNA demethylation by oxidizing 5-methylcytosine (5mC) in DNA to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC). Since these oxidized methylcytosines (oxi-mCs) are not recognized by the maintenance methyltransferase DNMT1, DNA dem...
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| Gepubliceerd in: | Genome Biol |
|---|---|
| Hoofdauteurs: | , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
BioMed Central
2021
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8218415/ https://ncbi.nlm.nih.gov/pubmed/34158086 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-021-02384-1 |
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