Roles of TET and TDG in DNA demethylation in proliferating and non-proliferating immune cells

BACKGROUND: TET enzymes mediate DNA demethylation by oxidizing 5-methylcytosine (5mC) in DNA to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC). Since these oxidized methylcytosines (oxi-mCs) are not recognized by the maintenance methyltransferase DNMT1, DNA dem...

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Dades bibliogràfiques
Publicat a:Genome Biol
Autors principals: Onodera, Atsushi, González-Avalos, Edahí, Lio, Chan-Wang Jerry, Georges, Romain O., Bellacosa, Alfonso, Nakayama, Toshinori, Rao, Anjana
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2021
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8218415/
https://ncbi.nlm.nih.gov/pubmed/34158086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-021-02384-1
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