Roles of TET and TDG in DNA demethylation in proliferating and non-proliferating immune cells

BACKGROUND: TET enzymes mediate DNA demethylation by oxidizing 5-methylcytosine (5mC) in DNA to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC). Since these oxidized methylcytosines (oxi-mCs) are not recognized by the maintenance methyltransferase DNMT1, DNA dem...

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Dettagli Bibliografici
Pubblicato in:Genome Biol
Autori principali: Onodera, Atsushi, González-Avalos, Edahí, Lio, Chan-Wang Jerry, Georges, Romain O., Bellacosa, Alfonso, Nakayama, Toshinori, Rao, Anjana
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2021
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8218415/
https://ncbi.nlm.nih.gov/pubmed/34158086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-021-02384-1
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