Epigenetic modulation of the drug resistance genes MGMT, ABCB1 and ABCG2 in glioblastoma multiforme

BACKGROUND: Resistance of the highly aggressive glioblastoma multiforme (GBM) to drug therapy is a major clinical problem resulting in a poor patient’s prognosis. Beside promoter methylation of the O( 6 )-methylguanine-DNA-methyltransferase (MGMT) gene the efflux transporters ABCB1 and ABCG2 have be...

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Autori principali: Oberstadt, Moritz C, Bien-Möller, Sandra, Weitmann, Kerstin, Herzog, Susann, Hentschel, Katharina, Rimmbach, Christian, Vogelgesang, Silke, Balz, Ellen, Fink, Matthias, Michael, Heike, Zeden, Jan-Philip, Bruckmüller, Henrike, Werk, Anneke N, Cascorbi, Ingolf, Hoffmann, Wolfgang, Rosskopf, Dieter, Schroeder, Henry WS, Kroemer, Heyo K
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2013
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3890604/
https://ncbi.nlm.nih.gov/pubmed/24380367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-13-617
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