MDR1‐P‐Glycoprotein (ABCB1) Mediates Transport of Alzheimer’s Amyloid‐β Peptides—Implications for the Mechanisms of Aβ Clearance at the Blood–Brain Barrier

Amyloid‐β (Aβ) is the major component of the insoluble amyloid plaques that accumulate intracerebrally in patients with Alzheimer’s disease (AD). It has been suggested that MDR1‐P‐glycoprotein (ABCB1, P‐gp) plays a substantial role in the elimination of Aβ from the brain. In the present study, MDR1‐...

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Detalhes bibliográficos
Publicado no:Brain Pathol
Main Authors: Kuhnke, Diana, Jedlitschky, Gabriele, Grube, Markus, Krohn, Markus, Jucker, Mathias, Mosyagin, Igor, Cascorbi, Ingolf, Walker, Lary C., Kroemer, Heyo K., Warzok, Rolf W., Vogelgesang, Silke
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2007
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8095502/
https://ncbi.nlm.nih.gov/pubmed/17610523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1750-3639.2007.00075.x
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