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Epigenetic modulation of the drug resistance genes MGMT, ABCB1 and ABCG2 in glioblastoma multiforme
BACKGROUND: Resistance of the highly aggressive glioblastoma multiforme (GBM) to drug therapy is a major clinical problem resulting in a poor patient’s prognosis. Beside promoter methylation of the O( 6 )-methylguanine-DNA-methyltransferase (MGMT) gene the efflux transporters ABCB1 and ABCG2 have be...
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Hauptverfasser: | , , , , , , , , , , , , , , , , , |
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Format: | Artigo |
Sprache: | Inglês |
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BioMed Central
2013
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Schlagworte: | |
Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3890604/ https://ncbi.nlm.nih.gov/pubmed/24380367 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-13-617 |
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