Beta-Amyloid Downregulates MDR1-P-Glycoprotein (Abcb1) Expression at the Blood-Brain Barrier in Mice

Neurovascular dysfunction is an important component of Alzheimer's disease, leading to reduced clearance across the blood-brain barrier and accumulation of neurotoxic β-amyloid (Aβ) peptides in the brain. It has been shown that the ABC transport protein P-glycoprotein (P-gp, ABCB1) is involved...

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Detalhes bibliográficos
Main Authors: Brenn, Anja, Grube, Markus, Peters, Michele, Fischer, Andrea, Jedlitschky, Gabriele, Kroemer, Heyo K., Warzok, Rolf W., Vogelgesang, Silke
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE-Hindawi Access to Research 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3109772/
https://ncbi.nlm.nih.gov/pubmed/21660212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4061/2011/690121
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