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PML isoforms in response to arsenic: high-resolution analysis of PML body structure and degradation

Arsenic is a clinically effective treatment for acute promyelocytic leukaemia (APL) in which the promyelocytic leukaemia (PML) protein is fused to retinoic receptor alpha (RARα). PML-RARα is degraded by the proteasome by a SUMO-dependent, ubiquitin-mediated pathway in response to arsenic treatment,...

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Bibliografske podrobnosti
Main Authors: Hands, Katherine J., Cuchet-Lourenco, Delphine, Everett, Roger D., Hay, Ronald T.
Format: Artigo
Jezik:Inglês
Izdano: The Company of Biologists 2014
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3889398/
https://ncbi.nlm.nih.gov/pubmed/24190887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.132290
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